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FRIDAY
Harrisburg (4-0) at Altoona (3-1), 7
Notable: Princeton Dent has rushed for 416 yards and eight touchdowns for Harrisburg this year.
Bald Eagle Area (3-1) at Philipsburg-Osceola (3-1), 7
Notable: The Eagles have beaten the Mountaineers 14 times in a row. P-O last won in this series in 2011.
Bedford (1-3) at Chestnut Ridge (1-3), 7
Notable: Ridge has won three of the last four and is 12-8 over the last 20 meetings in this rivalry.
Central Cambria (3-1) at Penn Cambria (3-1), 7
Notable: Goal Post Trophy hasn't been won by Red Devils since 2019 and CC has lost last two meetings 36-0.
Clearfield (1-3) at Huntingdon (1-3), 7
Notable: Bison haven't lost more than four games since 2017 but already have three losses through four games.
Tyrone (3-1) at Bellwood-Antis (3-1), 7:06
Notable: New Tyrone coach Jason Jones gets his first taste of the Eagles' biggest game -- the Backyard Brawl
Claysburg-Kimmel (0-4) at Juniata Valley (2-2), at Williamsburg H.S., 7
Notable: Green Hornets are 5-1 against Bulldogs since co-op began with Williamsburg in 2021.
Moshannon Valley (3-1) at Glendale (2-2), 7
Notable: Through four games, Knights' Rocco Reifer has 544 yards and five touchdowns rushing.
Northern Bedford (2-2) at Berlin Brothersvalley (4-0), 7
Notable: Black Panthers are playing a District 5 opponent on the field for the first time this year in Week 5.
Tussey Mountain (0-4) at Meyersdale (3-1), 7
Notable: Counting Meyersdale, the combined record of the teams the Titans have played this year is 15-5.
Cambria Heights (4-0) at Northern Cambria (2-2), 7
Notable: Highlanders lead the all-time series 27-24-1. Teams have met twice in the postseason, going 1-1.
Portage (2-2) at Conemaugh Township (3-1), 7
Notable: The Indians' Greyson Studer has thrown for 590 yards and run for 375 yards this season.
Hollidaysburg (3-1) at Fort Hill (Md.) (3-0), 7
Notable: Fort Hill has outscored its opponents 167-8 through three games this season.
SATURDAY
Central (4-0) at Bishop Guilfoyle (3-1), 7
Notable: Teams are 2-2 in the last four meetings, but Marauders won last year, 49-7.