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FRIDAY
Harrisburg (5-1) at Altoona (0-6), 7
Notable: In five meetings since Altoona rejoined the Mid-Penn Conference, Harrisburg is 5-0 and has outscored the Lions, 251-24.
Bedford (4-2) at Somerset (2-4), 7
Notable: Jacob Wilson has a team-high 61 tackles, an average of 10.2 per game, for Bedford so far this season.
Central Cambria (0-6) at Forest Hills (2-4), 7
Notable: Forest Hills leads three teams at 2-4 (along with Tyrone and P-O) in the D6 Class 3A rankings in the race for the No. 3 seed.
Penn Cambria (6-0) at Chestnut Ridge (4-2), 7
Notable: Haydan Webb has been a difference maker for the Lions with 10 TDs and 134 carries for 821 yards and a 6.1 per carry average.
Penns Valley (0-6) at Central (4-2), 7
Notable: Rams and Dragons have split the last four meetings. Prior to those games, Central had an 11-game winning streak in the series.
Philipsburg-Osceola (2-4) at Bellefonte (4-2), 7
Notable: Sam McDonald has been P-O QB Archer Baughman's main target this year. He's hauled in 31 passes for 450 yards.
Tyrone (2-4) at Huntingdon (0-6), 7
Notable: After Huntingdon won three in a row in the series from 2017-2019, Tyrone has won four straight, including a forfeit in 2021.
Westmont Hilltop (0-6) at McCort-Carroll (3-3), 7
Notable: McCort-Carroll currently leads a group of three teams (along with BEA and United) at 3-3 in 7th position in D6 Class 2A.
Glendale (4-2) at Claysburg-Kimmel (4-2), 7
Notable: The Bulldogs have won four straight, something they haven't done since 2019 when they won five straight and went 8-4.
Meyersdale (3-3) at Northern Bedford (5-1), 7
Notable: Red Raiders QB Lance Jones has thrown for 722 yards this season, and Spencer Whitfield is averaging 5.4 yards per carry.
Mount Union (5-1) at Juniata Valley (2-4), 7
Notable: Before the Trojans' win last year, Juniata Valley had won three straight in the series and has won 10 of the last 18 overall.
Tussey Mountain (1-5) at Berlin Brothersvalley (3-3), 7
Notable: These teams have met twice over the last 10 years, and the score has been 42-14 both times. Berlin won last year, Tussey in '13.
Cambria Heights (6-0) at Conemaugh Township (3-3), 7
Notable: The Indians only rush for 2.6 yards per carry, but their defense has been carrying them, allowing just 14.7 points per game.
Northern Cambria (5-1) at Penns Manor (5-1), 7
Notable: Teams have split the last 14 meetings, which included Northern Cambria's 12-6 win for the District 6 Class 1A title in 2022.
United Valley (3-3) at Portage (2-4), 7
Notable: Big game for both teams. United Valley is currently outside the field in 2A while Mustangs are hanging on to a low seed in 1A.
Jersey Shore (5-1) at Hollidaysburg (5-1), 7
Notable: Jersey Shore's only loss is to 6-0 Shamokin, which defeated Central Mountain by a 76-0 score on Sept. 20.
SATURDAY
Bellwood-Antis (5-1) at Bishop Guilfoyle (6-0), 7
Notable: The Marauders have won two straight in the series, but the teams met last season for the first time in nine years.
Moshannon Valley (4-2) at Curwensville (2-4), 7
Notable: The Black Knights are currently the No. 4 seed in the District 6 Class 1A playoff rankings and are 4-0 in the ICC North.
--Compiled by Michael Boytim