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Cumberland Valley (1-1) at Altoona (0-2), 7
Notable: CV has won eight of the last nine meetings with the lone exception coming in 2020.
Bedford (2-0) at Central Cambria (0-2), 7
Notable: Last year's 12-7 win by the Red Devils snapped a nine-game losing streak to Bedford in the series.
Central (1-1) at Tyrone (1-1), 7
Notable: Dragons have had the Eagles' number, winning eight of the last nine matchups.
Chestnut Ridge (1-1) at McCort-Carroll (1-1), 7
Notable: The Lions have won six in a row in the series, scoring at least 35 points in each of the last four games.
Clearfield (2-0) at Philipsburg-Osceola (1-1), 7
Notable: Clearfield has won 12 straight against P-O, including a forfeit, since a 40-33 P-O win in 2011.
Forest Hills (1-1) at Penn Cambria (2-0), 7
Notable: Penn Cambria has won the last two games and scored a combined 89 points in those wins.
Huntingdon (0-2) at Bellwood-Antis (2-0), 7
Notable: Both proud programs each won just two games last year, including Bearcats' win over Devils.
Berlin Brothersvalley (1-1) at Everett (2-0), 7
Notable: The matchup between these two teams last year was the first in 14 years. Berlin won both games.
Claysburg-Kimmel (0-2) at West Branch (0-2), 7
Notable: This will be West Branch's first game against a District 6 opponent this season.
Glendale (2-0) at Juniata Valley (1-1), 7
Notable: Vikings have lost nine in a row against Juniata Valley and 17 of the last 20 matchups in the series.
Moshannon Valley (0-2) at Southern Huntingdon (0-2), 7
Notable: Rockets had won three in a row in the series before the Black Knights won 54-0 last season.
Northern Bedford (2-0) at Wilmington (1-1), 7
Notable: Wilmington went 70-10 from 2016-2021, but the Greyhounds went just 7-13 the last two seasons.
Tussey Mountain (1-1) at Windber (1-1), 7
Notable: Windber has beaten Tussey in each of the last three seasons, scoring 169 points in those games.
Northern Cambria (2-0) at Conemaugh Valley (0-2) , 7
Notable: The Jays are playing Friday night home games for the second year after recently adding lights.
Portage (1-1) at River Valley (1-1), 7
Notable: The last two seasons, Portage won 40-6 in 2022, and River Valley won 41-6 last year.
Allegany (Md.) (0-2) at Hollidaysburg (2-0), 7
Notable: Allegany has beaten Hollidaysburg twice by one score the last two seasons by a combined 10 points.
SATURDAY
Bellefonte (2-0) at Bishop Guilfoyle (2-0), 7
Notable: The Red Raiders have defeated traditional powers Central and Chestnut Ridge to get to 2-0.
Cambria Heights (2-0) at Marion Center (2-0), 7
Notable: The Highlanders have won all four meetings against MC, scoring at least 34 points in each game.
-- Compiled by Michael Boytim