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Chiefs 30, Raiders 27
LAS VEGAS -- Patrick Mahomes remained undefeated at Allegiant Stadium, passing for 225 yards and two touchdowns, and Kenneth Walker III rushed for 177 yards and two TDs to lead Kansas City to a victory over Las Vegas.
Walker's 2-yard touchdown run with 3:21 left put the Chiefs (4-0) ahead for good at 23-19. It was set up by Tyquan Thornton's 55-yard reception on the previous play. Thornton, who had five catches for 111 yards and two touchdowns, suffered a gruesome-looking left leg injury on the play and was carted off.
Kirk Cousins passed for 365 yards and two touchdowns for the Raiders, ending his seven-game winning streak that included the final four games last season with Atlanta. Brock Bowers, who played with an illness, caught six passes for 86 yards and a TD.
Las Vegas' running game produced just 72 yards, averaging 2.8 per carry.
Seahawks 30, Chargers 23
SEATTLE -- Emanuel Wilson caught a touchdown pass and ran for another score and Seattle handed Los Angeles a fourth straight loss to start the season with a victory.
Sam Darnold threw for 168 yards and two touchdowns for the defending Super Bowl champions, who are 3-1 after rebounding from last week's 33-31 loss to the Washington Commanders.
Wilson rushed for 81 yards on 21 carries and caught three passes for 39 yards. The backup running back, in his first year with the Seahawks, was thrust into a greater role when rookie Jadarian Price was placed on injured reserve on Saturday after aggravating a chest injury during practice.
Colts 30, Commanders 13
LONDON -- Jonathan Taylor rushed for two touchdowns and Colts quarterback Daniel Jones ran one in and Indianapolis beat Washington after the Commanders lost yet another quarterback to injury.
Marcus Mariota, who was starting in place of the injured Jayden Daniels, left the game after Washington's second drive because of a knee injury. The veteran quarterback was sacked and didn't return for the Commanders (1-3).
Third-string rookie quarterback Athan Kaliakmanis threw his first NFL touchdown pass to cut Indy's lead to 17-13 in the third quarter, but the Colts (2-2) answered with Spencer Shrader's 52-yard field goal and Jones' 4-yard run early in the fourth quarter.
Packers 17, Buccaneers 14
TAMPA, Fla. -- Jordan Love threw two touchdown passes and Green Bay overcame two fourth-quarter turnovers to beat Tampa Bay.
Undrafted rookie Jalon Daniels threw two picks that led to 10 points in his first career start filling in for Baker Mayfield, who missed a game for the first time in his three-plus seasons in Tampa Bay because of a dislocated thumb.
Ravens 24, Titans 18
BALTIMORE -- Lamar Jackson threw for 222 yards and two touchdowns before leaving the game with an ankle injury, Derrick Henry scored against his former team, and Baltimore handled Tennessee.
Zay Flowers had eight catches for 118 yards and a TD for the Ravens, who snapped a four-game home losing streak but now have to deal with more health concerns about their two-time MVP quarterback. Jackson took a sack in the final seconds of the first half, and his left ankle appeared to roll under a Tennessee defender.
Bears 23, Jets 12
CHICAGO -- Kyle Monangai rushed for 146 yards and two touchdowns, and Chicago stuffed New York for a victory.
Devin Bush, Austin Booker and Dayo Odeyingbo each had a sack as Chicago limited New York to seven first downs and 157 yards overall. The Bears have allowed a total of 28 points in three games since their wild 59-37 victory at Carolina in their season opener.
Giants 36, Cardinals 24
EAST RUTHERFORD, N.J. -- Jameis Winston threw three touchdown passes to offset a pair of interceptions, Deonte Banks had a 98-yard pick-6 in the final seconds and New York won another not-so-pretty game, defeating Arizona.
Making his second start in place of injured franchise quarterback Jaxson Dart, Winston again did what he needed to do to engineer a victory with TD passes to Malachi Fields, Malik Nabers and Theo Johnson.
Jaguars 22, Bengals 17
CINCINNATI -- Trevor Lawrence passed for 227 yards and a touchdown, Jacksonville's defense forced two critical turnovers and the Jaguars held off Cincinnati.
Joe Burrow passed for 428 yards for the Bengals, who lost All-Pro wide receiver Ja'Marr Chase to a concussion in the second quarter. Tee Higgins had 11 receptions for 151 yards.
Burrow, who completed 39 of 54 passes, also had two interceptions -- one that Jacksonville converted into a touchdown and the other when the Bengals were in the red zone.
Cowboys 34, Texans 30
HOUSTON -- CeeDee Lamb had a career-high 17 catches for 189 yards and his 12-yard TD reception with 40 seconds left lifted Dallas to a win over Houston to keep the Texans winless.
Javonte Williams ran for a career-high three touchdowns -- all in the second half -- to help the Cowboys to the victory.
Vikings 15, Dolphins 10
MINNEAPOLIS -- Minnesota stayed undefeated with more dominance by their defense and five field goals from Will Reichard, sidestepping their early passing game problems to secure a victory over the winless Miami.
T.J. Hockenson had a career-high-tying 13 receptions for 119 yards on 13 targets from Kyler Murray, including the game-sealing 8-yard catch on third-and-5 from the 10. Hockenson was wide open and could've coasted into the end zone, but he wisely slid in front of the goal line to drain the clock down to the two-minute warning.
49ers 24, Broncos 14
SANTA CLARA, Calif. -- Brock Purdy threw two touchdown passes and Christian McCaffrey ran for a score to lead the undefeated San Francisco to a victory over Denver.
Both offenses struggled to generate offense on a hot day in the Bay Area, but the 49ers (4-0) took advantage of a fumbled punt return by Marvin Mims Jr. to set up a short touchdown drive in the third quarter that gave them the lead for good.