LOS ANGELES — If Southern California wants to win its first national championship in 41 years, the Trojans will have to find a way to get it done without star guard JuJu Watkins.

They notched their 30th win for the first time since 1986 by walloping ninth-seeded Mississippi State 96-59 in the second round of the NCAA Tournament on Monday night. But they lost Watkins to a season-ending right knee injury in the first quarter.

She was streaking down the court on a fast break with two Bulldogs defenders nearby when her knee bent awkwardly as she planted her right foot. She immediately crumpled to the court. Watkins had to be carried off, unable to put any weight on her leg. She will have surgery and then rehabilitate, USC said, without specifying her injury.

The sight of Watkins writhing in pain on the court, holding her injured knee while her teammates stood around her and coach Lindsay Gottlieb rushed to the 19-year-old’s side shocked the crowd of 7,808 at Galen Center.

“JuJu is a generational talent,” Mississippi State guard Jerkaila Jordan said. “She’s changed the game in so many ways at such a young age. Seeing her go down was really tough. I said my prayers for her.”

Losing Watkins just five minutes in on a non-contact play turned the home fans angry and they booed the Bulldogs the rest of the game. At halftime, they jeered the MSU cheerleaders’ routine.

“You had to be here to feel it,” Gottlieb said. “I don’t know if people saw that through the TV, but it was a palpable thing.”

The top-seeded Trojans, meanwhile, were all business. Buoyed by the raucous crowd, they hit buzzer-beating shots at the end of the first, second and third quarters and ran their lead to 46 points in the fourth.

“I wouldn’t say this is our defining moment,” said Kiki Iriafen, who scored a season-high 36 points. “It’s what we expect of ourselves. We expect to win in this tournament regardless if it’s going our way, we have people, we don’t have people. That’s the standard here.”

Next up is the Sweet 16 in Spokane, Washington, where the Trojans (30-3) play fifth-seeded Kansas State (28-7) on Friday.

No expansion yet

Expanding the men’s NCAA Tournament would not be a good move for women’s March Madness.

The numbers don’t add up, though that may not matter.

If the men’s field expands to 72 or 76 teams as has been a topic of conversation the last few months, it would be almost a foregone conclusion that the women’s field would grow as well for equity reasons. Though it is questionable whether the men’s tourney is ready for expansion, it seems clear women’s March Madness is not. It’s not ready from a competitive or a financial standpoint.

Coaches have mixed feelings on expansion.