Drake Maye makes his first career start for the 1-4 Patriots (+7) against a defense that just held Josh Allen to a 30% completion rate.

The Texans (4-1) have 15 sacks and could feast on a rookie quarterback playing behind a woeful offensive line. C.J. Stroud won’t have top receiver Nico Collins. Best bet: Texans, 26-16

Elsewhere:

Jacksonville vs. Chicago (-2), in London: The Jaguars (1-4) head abroad for the first of two straight games in London. Tank Bigsby and Travis Etienne lead the second-best run offense in the NFL and Trevor Lawrence is coming off his best game of the season. The Bears (3-2) are starting to click on offense behind Caleb Williams’ passing and D’Andre Swift’s running. Upset special: Jaguars, 22-20

Arizona at Green Bay (-5): The Packers (3-2) won’t overlook the Cardinals (2-3) after Arizona’s surprising comeback win in San Francisco. Jordan Love needs to protect the ball better for Green Bay. He has five interceptions in his three starts. Love will have receiver Romeo Doubs back this week so that should help. The Cardinals can score points. Packers, 27-20

Indianapolis (-1) at Tennessee: Quarterback Anthony Richardson, Pro Bowl center Ryan Kelly and 2021 NFL rushing champ Jonathan Taylor are uncertain again for the Colts (2-3). But they have Joe Flacco, who has excelled, in case Richardson can’t go. Indianapolis’ problem is a league-worst defense. Colts, 23-17

Tampa Bay (-3.5) at New Orleans: The Buccaneers (3-2) are coming off a gut-wrenching overtime loss to Atlanta and went to New Orleans early to escape Hurricane Milton. Baker Mayfield and Tampa Bay’s offense are starting fast but need to finish stronger. The Saints (2-3) have crashed after opening with two routs. Buccaneers, 19-17

Cleveland at Philadelphia (-9): The Eagles (2-2) had a week off to think about an embarrassing loss to the Buccaneers. They should be focused and eager to go. Jalen Hurts could have more help if receivers A.J. Brown and DeVonta Smith return along with Pro Bowl right tackle Lane Johnson. The Browns (1-4) hardly look like last year’s playoff team. Eagles, 24-20

Washington at Baltimore (-6.5): Lamar Jackson is playing like a two-time NFL MVP, Derrick Henry is the best running back in the NFL and the Ravens (3-2) have come a long way since losing their first two games. The Commanders (4-1) have been impressive behind rookie QB Jayden Daniels. Ravens, 29-21

Los Angeles Chargers (-3) at Denver: Jim Harbaugh vs. Sean Payton is an intriguing matchup. The Chargers (2-2) have lost two in a row. The Broncos (3-2) have won three straight. Yet, Denver is a home underdog. Chargers, 23-18

Pittsburgh (-3) at Las Vegas: Two teams with uncertainty at quarterback face off in a rivalry that goes back to Franco Harris’ “Immaculate Reception.” Justin Fields has been developing for the Steelers (3-2), but the offense is averaging just 18.4 points per game. Once Russell Wilson is healthy to play, coach Mike Tomlin has to make a decision he’s been avoiding. The Raiders (2-3) will have Aidan O’Connell replacing Gardner Minshew. But T.J. Watt still won’t make it a fun day for Las Vegas. Steelers, 20-16

Detroit (-3) at Dallas: The banged-up Cowboys (3-2) are 0-2 at home and have allowed 72 points in those games. And, they had Micah Parsons and DeMarcus Lawrence. Both are out again this week, putting more pressure on Dak Prescott and the offense to outscore Detroit (3-1) in a shootout. Lions, 33-24

Atlanta (-6) at Carolina: Comeback Kirk Cousins has found a rhythm in Atlanta’s offense. The Falcons (3-2) just need to avoid overlooking the Panthers (1-4) with tougher games ahead. Falcons, 30-16

Cincinnati (-3.5) at New York Giants: Joe Burrow says the Bengals (1-4) aren’t a “championship-level” team right now. He’s right. But they’re better than their record and that’s why they’re favorites on the road against the Giants (2-3). New York is improving behind Daniel Jones and coming off an impressive road win at Seattle without top receiver Malik Nabers and No. 1 running back Devin Singletary. Bengals, 27-20

Buffalo (-2.5) at New York Jets: Interim coach Jeff Ulbrich makes his debut after Robert Saleh was fired. The Jets (2-3) need Ulbrich, who was the defensive coordinator, to spark an offense that’s been inconsistent even with Aaron Rodgers under center. The Bills (3-2) have cooled off after a hot start. But they’ve never lost three straight games with Josh Allen. Jets, 23-20

Last week: Straight up: 8-6. Against spread: 7-7.

Overall: Straight up: 50-28. Against spread: 41-35-2.

Thursday: Straight up: 4-1. Against spread: 3-2.

Monday: Straight up: 4-3. Against spread: 2-5.

Best Bet: Straight up: 3-2. Against spread: 3-2.

Upset Special: Straight up: 4-1. Against spread: 4-1.