Look for champion Seattle Seahawks to hand Kansas City Chiefs their first setback
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Running back Kenneth Walker III is going back to Seattle with the undefeated Kansas City Chiefs to face the team he helped lead to the Super Bowl title last season.
Walker, Patrick Mahomes and the Chiefs (+2.5) visit the Seahawks (3-3) on Sunday night.
Pro Picks likes the home team. Seahawks, 23-20
Elsewhere:
PITTSBURGH (-3) vs. NEW ORLEANS (2-4), in Paris: Aaron Rodgers led the Steelers back from a 13-point deficit in Tampa Bay, relying on DK Metcalf and rookie Germie Bernard. The Saints got their run game going in a win over the Giants. Both teams are spending the week in Paris before playing the NFL's first regular-season game there. The Steelers have covered the spread four of the past five games. Steelers, 23-18
CINCINNATI at BALTIMORE (-2.5): Joe Burrow and the Bengals are coming off a bye. Their defense had a great start but has struggled against the run in the past three games. The Ravens still might not have Lamar Jackson so Tyler Huntley would start his third straight game. Baltimore is eighth in rushing and relying on Derrick Henry is a smart move if Jackson is out. Bengals, 22-17
CLEVELAND (-1.5) at TENNESSEE: Deshaun Watson led another fourth-quarter game-winning drive for the Browns, but the offense has struggled despite the team's winning record. Tennessee's offense is last in the NFL. The Titans beat the Colts for their first win, but Cam Ward had another rough outing. UPSET SPECIAL: Titans, 20-17
INDIANAPOLIS at MINNESOTA (-6.5): The Colts' struggles cost general manager Chris Ballard his job. Coach Shane Steichen is clearly on the hottest of seats and the team has to find ways to win. The undefeated Vikings are coming off a bye. They've been winning on defense and special teams and need Kyler Murray to get the offense going. Vikings, 23-18
MIAMI at NEW YORK JETS (-4.5): The Jets haven't won an AFC East game under coach Aaron Glenn, going 0-7. They have their best chance this week vs. Miami. The winless Dolphins are coming off a bye. QB Malik Willis has the worst passer rating (68.4) among starters. Jets, 20-17
NEW YORK GIANTS at HOUSTON (-10.5): J.J. McCarthy is replacing Jameis Winston, who had a winning record after taking over for Jaxson Dart. McCarthy will face an underachieving defense stacked with talent. C.J. Stroud is playing great football for the Texans, who've won two in a row. Texans, 26-17
SAN FRANCISCO (-3.5) at ATLANTA (2-4): Christian McCaffrey vs. Bijan Robinson in a matchup of All-Pro backs who are close friends and train together. The undefeated 49ers keep winning despite losing key players because they have Brock Purdy. The Falcons lost two games to start the season, won two in a row and have now lost two straight. Atlanta is 3-2 ATS in past five games against San Francisco. 49ers, 22-20
TAMPA BAY at CAROLINA (-3.5): Baker Mayfield is aiming to return for the Buccaneers, who have lost 12 of their past 15 games. The Bucs have played tough defense but their offense is among the bottom third. Bryce Young is playing his best football for the Panthers. He has 11 TDs and only two picks. Panthers, 23-20
DENVER (-4.5) at ARIZONA: Bo Nix is taking plenty of heat despite Denver's winning record. Nix and the offense have to get on track. The Broncos have faced a tough schedule that doesn't get easier after Arizona. The Cardinals beat the Rams on the road last week and have to carry that momentum into a difficult matchup. Broncos, 24-16
GREEN BAY at DETROIT (-3): The Packers have won three in a row, the defense has been out and Josh Jacobs is coming back to boost the offense with Micah Parsons working toward his return. The Lions have the league's worst defense that's sometimes offset by a prolific offense. This one should be a shootout. Lions, 30-26
LOS ANGELES RAMS (-4.5) at LAS VEGAS: The Rams haven't played close to Super Bowl favorites. And, injuries are piling up with Davante Adams now going down for several weeks. But they still have Sean McVay, Matthew Stafford, Puka Nacua and Aaron Donald. The Raiders have lost three in a row but Kirk Cousins is playing well so hold off on Fernando Mendoza. A defense that's allowed 30-plus points three straight games has been the problem. BEST BET: Rams, 31-20
DALLAS (-4.5) at PHILADELPHIA: The Cowboys have an opportunity in a wide-open NFC East, but have had issues on defense and now a dynamic offense has sputtered. The Eagles are reeling and won't have Jalen Hurts likely for the rest of the season. Tanner McKee makes his second straight start for Philadelphia. Cowboys, 24-23
Last week: Straight up: 8-6. Against spread: 7-7.
Overall: Straight up: 55-37-1. Against spread: 45-45-2.
Best Bet: Straight up: 3-3. Against spread: 2-4.
Upset Special: Straight up: 2-4. Against spread: 2-4.