The New Orleans Saints are 2-0 under interim coach Darren Rizzi and are coming off a bye with a chance to keep their playoff hopes alive.

Alvin Kamara should be excited to get the ball against the Los Angels Rams (-2.5), who just gave up 255 yards rushing to Saquon Barkley. Upset special: Saints, 24-23

Elsewhere:

Los Angeles Chargers (-2) at Atlanta: The Chargers hit the road on a short week after losing the “Harbowl” at home to the Ravens. Their offense could be without running back J.K. Dobbins and the defense has allowed 57 points in the past two games after giving up just 13.6 per game the previous five. Meanwhile, the rested Falcons are coming off a bye and eager to snap a two-game losing streak. Falcons 23-22

Pittsburgh at Cincinnati (-3): The AFC North-leading Steelers are road underdogs following a road loss at Cleveland. Russell Wilson has been hitting his deep throws but needs better protection. A usually stingy defense that couldn’t make stops against Jameis Winston in the snow now has to contain Joe Burrow, Ja’Marr Chase and Tee Higgins. The underachieving Bengals need to stack wins to have any shot at climbing back into the playoff race. Cincinnati is 1-3 ATS as a home favorite this season. Bengals, 24-23

Arizona at Minnesota (-3.5): Stout defense and solid play by QB Sam Darnold has helped Minnesota become the surprise team in the NFL this season. Only the Lions and Chiefs have a better record. The Cardinals are in a four-way battle in the NFC West. A disappointing offensive performance led to their four-game winning streak being snapped. Vikings, 23-17

Indianapolis (-2.5) at New England: It’s no longer Tom Brady vs. Peyton Manning in this rivalry. Anthony Richardson and Drake Maye go head-to-head in a matchup between young QBs taken in the top five of the draft over the past two seasons. The Colts can’t get their offense and defense to play well in the same game. Colts, 20-16

Seattle (-2) at New York Jets: Geno Smith faces the team that drafted him after turning his career around on his fourth stop and going to the Pro Bowl the past two seasons. The Seahawks are fighting for the playoffs while the Jets have fallen apart. Their coach and GM already have been fired. Aaron Rodgers’ future is uncertain. Yet, the team still has plenty of talent. Seahawks, 20-17

Tennessee at Washington (-6): Jayden Daniels and the Commanders have hit a detour on their road to the playoffs, losing three straight games. The Titans are coming off a big upset in Houston and Will Levis has asserted himself since returning from an injury a month ago. Commanders, 24-17

Houston (-4.5) at Jacksonville: C.J. Stroud and the Texans are having some issues this season. Not even close to Jacksonville’s troubles, though. The Jaguars could have Trevor Lawrence back after he missed two games. That won’t be enough. Houston has won 11 of the past 13 games vs. Jacksonville. The Texans are 2-6 ATS in their past eight games vs. AFC opponents. The Jaguars are 4-1 ATS in their past five games. Texans, 24-20

Tampa Bay (-6) at Carolina: Panthers coach Dave Canales has the team playing better and Bryce Young is showing some of the potential that made him a No. 1 overall pick. Canales’ familiarity with Baker Mayfield and Tampa Bay’s offense should help Carolina’s defense. The Buccaneers can’t afford a letdown as they try to make a push to get back in the playoff race. They’re getting key players healthy. Buccaneers, 24-20

Philadelphia at Baltimore (-3): Both teams are coming off impressive wins in the same stadium in Los Angeles one night apart. The Ravens had shorter rest following the Monday night win. Saquon Barkley has been a sensational addition for the Eagles. Derrick Henry has made a major impact in Baltimore. Jalen Hurts and Lamar Jackson go head-to-head for the first time. The Ravens have won two in a row in the series. Philadelphia has the better defense and that could be the difference. Eagles, 26-23

San Francisco at Buffalo (-7): The inconsistent 49ers need Brock Purdy, Trent Williams and Nick Bosa back from injuries. The defending NFC champions have lost two in a row, but they’re only one game back in their division. The rested Bills have won six in a row and are coming off a bye. Josh Allen in the MVP favorite and Buffalo can clinch another division title this weekend. Bills, 26-23

Cleveland at Denver (-5.5): Maybe Jameis Winston gets to play in the snow again. Winston has reinvigorated the Browns, though too late for it to matter this season. Rookie QB Bo Nix has helped turn the Broncos into a playoff contender. Broncos, 23-19

Last week: Straight up: 9-4. Against spread: 8-5.

Overall: Straight up: 121-68. Against spread: 97-80-2.

Prime-time: Straight up: 28-12. Against spread: 21-18-1.

Best Bet: Straight up: 8-4. Against spread: 7-5.

Upset Special: Straight up: 7-5. Against spread: 7-5.